Exploring the Therapeutic Rationale for Angiogenesis Blockade in Cervical Cancer
نویسندگان
چکیده
منابع مشابه
Beyond angiogenesis blockade: targeted therapy for advanced cervical cancer
The global burden of advanced stage cervical cancer remains significant, particular in resource poor countries where effective screening programs are absent. Unfortunately, a proportion of patients will be diagnosed with advanced stage disease, and may suffer from persistent or recurrent disease despite treatment with combination chemotherapy and radiation. Patients with recurrent disease have ...
متن کاملExploring the Impact of Individual Factors in Taking Cervical Cancer Screening: A Content Analysis
Background: Cervical cancer remains the leading cause of cancer death among women in developing country. In Iraqi Kurdistan Region, few women undergo screening and the incidence of cervical cancer is on the increase as is the case in most developing countries. The purpose of this study was to explore women’s individual factors affecting the performance of the cervical cancer screening in ...
متن کاملScreening for cervical cancer: recommendations and rationale.
The USPSTF found good evidence from multiple observational studies that screening with cervical cytology (Pap smears) reduces incidence of and mortality from cervical cancer. Direct evidence to determine the optimal starting and stopping age and interval for screening is limited. Indirect evidence suggests most of the benefit can be obtained by beginning screening within 3 years of onset of sex...
متن کاملNew strategies in advanced cervical cancer: from angiogenesis blockade to immunotherapy.
Cervical cancer remains unique among solid tumor malignancies. Persistent infection with oncogenic subtypes of the human papillomavirus (HPV) results in carcinogenesis, predominantly occurring at the cervical transformation zone where endocervical columnar cells undergo metaplasia to a stratified squamous epithelium. The molecular cascade involving viral oncoproteins, E6 and E7 and their degrad...
متن کاملAngiogenesis Inhibitors in the Treatment of Breast Cancer: Exploring Avenues of New Therapeutic Targets
Angiogenesis is the physiological process through which new blood vessels form from pre-existing blood vessels and it is a critical part of development and wound healing [1]. This vascular network can originate in three ways: new blood vessels can sprout from existing vessels; new vessels can arise from bone marrow derived endothelial progenitor cells; or capillary walls can invaginate into the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Therapeutics
سال: 2015
ISSN: 0149-2918
DOI: 10.1016/j.clinthera.2014.11.012